HORDB

ID: hor001826
Uniprot ID: Q705J7
Protein name: Leucomyosuppressin
Gene name: lms
Organism: Blattella germanica (German cockroach) (Blatta germanica)
Family: FMRFamide related peptide family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Blattella (genus), Blattellinae (subfamily), Ectobiidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: NA

Sequence: QDVDHVFLRF
Length: 10
Propeptide: MKYVSVVLISVLAVLLACMPHMASAVPPPQCSPNILDDVPPRVRKVCAALSTIYELSNAMEAYLDDKVVRENTPLVDTGVKRQDVDHVFLRFGRRR
Signal peptide: MKYVSVVLISVLAVLLACMPHMASA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Inhibited food intake;elicited a powerful myoinhibitory effect on B. germanica foregut and hindgut
Mechanism: NA
Cross BBB: NO
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: 10(-10) M
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001826_AF2.pdb

hor001826_ESM.pdb

Mass:	143615	Formula:	C59H86N16O16
Absent amino acids:	ACEGIKMNPSTWY	Common amino acids:	DFV
pI:	5.41	Basic residues:	2
Polar residues:	0	Hydrophobic residues:	5
Hydrophobicity:	-4	Boman Index:	-2360
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	97
Instability Index:	3249	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 15093704
Title: Identification of Leucomyosuppressin in the German Cockroach, Blattella Germanica, as an Inhibitor of Food Intake